New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Burt Hopkins's The Philosophy of Husserl presents a challenging and thoughtful elucidation of Husserl's phenomenology that pays special attention to important methodological aspects of Husserl's philosophy, and, thereby, to Husserl's characterization of phenomenology as a pure and transcendental philosophy. Unlike other texts that attempt to elucidate Husserl's philosophy, Hopkins carries out his project in an unusual fashion, by beginning with a consideration of the conflict between Plato and Aristotle regarding the meaning and status of the eide, and ending with a (...) systematic critique of two of Husserl's most fierce opponents, Heidegger and Derrida. This review essay gives an overview of Hopkins's book and offers some critical remarks. (shrink)

In this essay I argue that the Stranger’s interest in keeping the philosopher and the sophist distinct is connected, primarily, to his assessment of the charges ofsophistry advanced against Socrates, which compels him to defend Socrates from these unduly advanced accusations. On this basis, I establish that the Stranger’s task in the Sophist, namely to keep philosophy distinct from sophistry, is intimately tied to the project of securing justice and is therefore not merely of theoretical importance but is also—and essentially—of (...) political and ethical significance. (shrink)

In this article, I argue that the just society is vegetarian. However, I do so in a way not commonly attempted by contemporary animal rights theorists, insofar as I appeal to Plato to make my case. Although there are certainly other ways to argue for this position, appealing to Plato is a significant and interesting way to lend historical credibility to this argument, and as such, the argument offered in this article provides an important contribution to existing analyses that attempt (...) to establish that humans ought to be vegetarians. (shrink)

In this paper I provide a compelling argument against the thesis that Aristotle’s understanding of the relation between the soul and the body can be construed asfunctionalist, despite some passages that would seem to support such an interpretation. Toward this end, in section I of the essay I offer an interpretation of Aristotle’s account of the soul-body relation that emphasizes the non-contingent nature of the connection between the soul and a specific kind of body, arguing that Aristotle’s account of the (...) soul as the “form” and “actuality” of the living thing, and of the organic body as its “matter” and “potentiality,” shows their necessary relation with one another. In section II, I present the functionalist account of mind, placing especial emphasis on its post-Cartesian genesis, which takes seriously the “problematic” status of the relation between mind and body. I then attempt to show, in section III, how because functionalism holds that psychic capacities can be realized within a number of different material bases, including physical and artificial systems, it is incompatible with Aristotle’s conception of the necessary soul-body relation, and thus that Aristotle’s account of psuche is not best construed as functionalist. (shrink)

In the last three decades, the consideration of whether non-human animals should be ascribed any moral status, and if so in what way it ought to be ascribed to them, has become of central philosophical, political and economic importance. Thus, given thecontemporary significance of what may be called (jar simplicity’s sake) the “animal issue,” it is worthwhile to examine in what way Ancient Greek philosophy might contribute to our understanding of the issue and to our philosophical response to it. With (...) this in mind,in this essay I examine the issue of the moral status of animals from a “critical” Aristotelian perspective, on the basis of which I shall attempt: (§I) to show how, unlike the Cartesian view of animal nature, Aristotle’s conception of the non-moral status of animals stillinforms the prevailing contemporary view of the animal, and (§II) to establish that Aristotle’s failure to ascribe moral status to animals should be rejected (a) given his admission that animals are, by nature, capable of suffering while they are unable to engage in rational deliberation, and (b) given his understanding of the connection between moral blameworthiness, natural disposition, and various kinds of acts, particularly un-chosen and chosen willing acts. In this way, we shall show that although the prevailing contemporary view of the animal’s moral status represents a slightly more “elevated” view than Aristotle’s, insofar as (typically) we do not explicitly claim, as Aristotle did, that animals are due no moral consideration, by critically appropriating the relevant Aristotelian texts, we nonetheless findrich philosophical evidence that permits us to further elevate our conception of the moral status of animals such that we are prepared to grant them genuine moral significance, not just in theory but also in practice. (shrink)

L’esperienza dell’istante is a book with two faces. On one hand it is an introduction to and commentary on Carlo Sini’s work; on the other hand it investigates the relationship between time and writing, time and utopian thinking, time and ethics. The opening section of the book begins with an analysis of Socrates’ attitude toward writing as it is shown in the Phaedrus. Carrera offers that by refusing to write, while at the same time claiming the role of judge as (...) far as the viability of writing is concerned, Socrates lays out the blueprint for any metaphysical judgment to come: Metaphysics is entitled to question the role of writing insofar as it takes no part in it, claiming that its authority comes from the unwritten voice instead—the voice of the soul. In the same manner, metaphysics judges the world and imposes its values on it by pretending to be removed from the world’s contingency. (shrink)

In this article we present (1) a close paraphrase--virtually a translation--of Heidegger's Sein und Zeit, §74, "Die Grundverfassung der Geschichtlichkeit," pp. 382-387, together with an analytical outline found in the Appendix; and (2) a brief commentary on the text. What Heidegger says about his own translation of Aristotle's Physics B 1 applies here as well: "The ‘translation' is already the interpretation proper. Thereafter only an explanation of the ‘translation' is called for.".

Due to natural phenomena like global warming and climate change, agricultural production is increasingly faced with threats that transcend farm boundaries. Management practices at the landscape or community level are often required to adequately respond to these new challenges (e.g., pest migration). Such decision-making at a community or beyond-farm level—i.e., practices that are jointly developed by farmers within a community—can be aided by computing and communications technology. In this study, we employ a translational research process to examine the social and (...) behavioral drivers of adoption of smart and connected farm networks among commodity crop farmers in the United States. We implement focus groups and questionnaires to bring to the fore views on the use of digital technologies in collaborative contexts. We find that participating farmers are concerned with several issues about the potential features of the network (e.g., the ability to ensure data validity while maintaining data privacy) and the nature of their interactions with the various stakeholders involved in the network management. The participatory approach we adopt helps provide insights into the process of developing technologies that are both actionable and trusted by potential end users. (shrink)

Alzheimer's disease is the most common form of dementia that gradually disrupts the brain network to impair memory, language and cognition. While the amyloid hypothesis remains the leading proposed mechanism to explain AD pathophysiology, anti-amyloid therapeutic strategies have yet to translate into useful therapies, suggesting that amyloid β-protein and its precursor, the amyloid precursor protein are but a part of the disease cascade. Further, risk of AD can be modulated by a number of factors, the most impactful being the ɛ4 (...) isoform of apolipoprotein E. A recent study reported a novel isoform-dependent transcriptional regulation of APP by apoE. These interesting new results add to the myriad of mechanisms that have been proposed to explain how apoE4 enhances AD risk, highlighting the complexities of not only apoE and AD pathophysiology, but also of disease itself. Also see the video abstract here: https://youtu.be/yd14MBdPkCY APP transcription is differentially modulated by apoE and its isoforms: how does this novel mechanism fit with the existing hypotheses? (shrink)

Les etudes ici rassemblees interrogent les articulations et desarticulations que Jean-Francois Lyotard place au principe du langage. Le volume dessine ainsi les lignes de force et les deplacements de sa pensee, ses presupposes et ses apories. Il montre les malentendus et les polemiques suscites par sa reecriture radicale de la rationalite. Pas de langage en general, dit Lyotard, mais des langages multiples, des types de discours heterogenes que la politique brasse sans pacifier leurs conflits. La recherche du consensus, dont l' (...) ethique de la discussion a souligne l'importance, tend a occulter les differends qui divisent les fins respectives des genres de discours. On ne peut pas etre pacifiste en matiere de phrases, et pas indifferent. Car tout enchainement discursif signe la victoire d'un genre et porte tort aux autres. Sans compter que la parole, quel qu'en soit le registre, eclipse par principe ce qui echappe aux contraintes linguistiques, ce champ de la sensation et du sentiment que Discours, figure explorait, des 1971, en inventant le figural. Apres 1983, apres l' ontologie des phrases du Differend, Lyotard cherche a cerner ce que les mots laissent en souffrance et dont ils doivent pourtant temoigner. Phrase-affect, infantia, donation sensible, Chose sont quelques-uns des noms sous lesquels il pense alors ce qui resiste au langage, le travaille de l'interieur et signe la difficulte de l'ecriture.Ont participe a ce volume Isabelle Aubert, Geoffrey Bennington, Gaelle Bernard, Corinne Enaudeau, Frederic Fruteau de Laclos, Alberto Gualandi, Laurence Kahn, Charlotte Murgier, Andreas Niederberger, Sophie Nordmann, Michel Olivier, Claire Pages, Ronit Peleg, Gerard Raulet, Jean-Francois Rey, Jean-Michel Salanskis, Francois-David Sebbah, Gerald Sfez, Rieke Trimcev. (shrink)

Western media coverage of female genital modifications in Africa has been hyperbolic and one-sided, presenting them uniformly as mutilation and ignoring the cultural complexities that underlie these practices. Even if we ultimately decide that female genital modifications should be abandoned, the debate around them should be grounded in a better account of the facts.

How does the philosophical problem about mental processes and states and behaviourism arise?—The first step is the one that altogether escapes notice. We talk of processes and states and leave their nature undecided. Sometimes perhaps we shall know more about them—we think. But that is just what commits us to a particular way of looking at the matter. And now the analogy which was to make us understand our thoughts falls to pieces. So we have to deny the yet uncomprehended (...) process in the yet unexplored medium. And now it looks as if we had denied mental processes. And naturally we don’t want to deny them. (shrink)

How does the philosophical problem about mental processes and states and behaviourism arise?—The first step is the one that altogether escapes notice. We talk of processes and states and leave their nature undecided. Sometimes perhaps we shall know more about them—we think. But that is just what commits us to a particular way of looking at the matter. And now the analogy which was to make us understand our thoughts falls to pieces. So we have to deny the yet uncomprehended (...) process in the yet unexplored medium. And now it looks as if we had denied mental processes. And naturally we don’t want to deny them. (shrink)

This essay examines an aesthetics of disgust through an analysis of the work of Scottish painter Jenny Saville. Saville's paintings suggest that there is something valuable in retaining and interrogating our immediate and seemingly unambivalent reactions of disgust. I contrast Saville's representations of disgust to the repudiation of disgust that characterizes contemporary corporeal politics. Drawing on the theoretical work of Elspeth Probyn and Julia Kristeva, I suggest that an aesthetics of disgust reveals the fundamental ambiguity of embodiment, allowing us (...) to critically attend to the aesthetic and cultural objectification of the female body. (shrink)

Les protestantes et leur contribution à l’émancipation des femmes sont sorties d’une zone d’ombre ces dernières années. Pourtant il reste encore beaucoup à apprendre sur les divers champs d’intervention et les luttes multiformes que rappelle Michelle Perrot, dans l’introduction de ce numéro thématique du Bulletin de la Société de l’Histoire du Protestantisme français : éducation des jeunes enfants, aide à l’enfance en difficulté, santé, hôpitaux, prisons… La modernité de l’analyse des protest...

Cretan icons often displayed a precious decoration of golden halos with incised, stippled, and/or impressed designs. The present study points out that these motifs should not be interpreted as manifestations of nostalgic and anachronistic attitudes on the part of post-Byzantine painters working in Candia for Greek Orthodox and Catholic clients. Rather, they appear already in several early Cretan works dating around 1400, which took inspiration from technical devices and ornamental motifs worked out in the workshops of Venice during the second (...) half of the fourteenth century and appropriated in icon painting probably through the mediation of mixed-style works produced in both the lagoon region and Venetian-ruled Candia. (shrink)

The problem of explaining color perception has fascinated painters, philosophers and scientists throughout the history. In many cases, the ideas and discoveries about color perception in one of these categories influenced the others, thus resulting in one of the most remarkable cross-fertilization of human thought. At the end of the nineteenth century, two models stood out as the most convincing ones: Young-Helmholtz’s trichromacy on one side, and Hering’s opponency on the other side. The former was mainly supported by painters and (...) scientists, although with some noticeable exceptions as, e.g., Otto Runge, while the majority of philosophers supported the latter. These two apparently incompatible models were proven to be two complementary parts of the hugely complex chain of events which leads to human color perception. Recently, a rigorous mathematical theory able to incorporate both trichromacy and opponency has been developed thanks to the use of the language and tools of quantum information. In this paper, we discuss the placement of this model within the philosophical theories about color. (shrink)

Article Paul Géhin/Michel Cacouros/Christian Förstel/Marie-Odile Germain/Philippe Hoffmann/Corinne Jouanno/Brigitte Mondrain avec la collaboration de Dominique Grosdidiers de Matons. Les manuscrits datés des XIIIe et XIVe siècles conservés dans les bibliothèques publiques de France was published on April 1, 2007 in the journal Byzantinische Zeitschrift (volume 100, issue 2).

This essay analyses the way in which the relation between surface and depth in modern painting is endowed with philosophical significance in the work of Michel Foucault, Maurice Merleau-Ponty and Michel Henry. Whereas Foucault considered the work of Magritte and Manet to undermine the notion of depth as such, by showing the movement of ‘similitude’, Merleau-Ponty and Henry saw post-impressionist painting as engendering an experience of depth that exceeds the Cartesian model of space as res extensa. The motif of painterly (...) surface thus brings into debate two significant movements in French twentieth-century thought: structuralism and phenomenology; in each case, the engagement with painterly technique becomes a way of grasping broader questions regarding the relation between perceptual experience and linguistic meaning. (shrink)

One of humans’ distinctive cognitive abilities is that they develop an array of capacities through an enculturation process. In “Cognition as a Social Skill,” Sally points to one of the dangers associated with enculturation: ideological oppression. To conceptualize how such oppression takes root, Haslanager appeals to notions of mindshaping and social coordination, whereby people participate in oppressive social practices unthinkingly or even willingly. Arguably, an appeal to mindshaping provides a new kind of argument, grounded in philosophy of mind, which supports (...) the claims that feminist and anti-racist want to defend. However, some theorists worry that Haslanger’s account does not shed much light on how individuals could exert their agency to resist oppression. I argue that enactivist conceptions of mindshaping and habit can help us to make sense of the power of social influences and how they have the potential to both enable and undermine cognition and agency. This moves us toward increased understanding of the workings of social oppression—distinguishing between constructive and enabling forms of heteronomy, and overdetermining and pernicious modes that lead to atrophied moral cognition and a narrowing of the field of affordances. (shrink)

Researchers have emphasized the value of authenticity, but not much is known about what makes a person authentic in the eyes of others. Our research takes an interpersonal perspective to examine the determinants of followers’ perceptions of leader authenticity. Building on social identity theory, we propose that two fundamental self-identifications–a leader’s sense of uniqueness and sense of belongingness–interact to influence followers’ perceptions of a leader’s authenticity via perceptions of a leader’s self-concept consistency. In a field study conducted among leader–follower dyads (...) and in a controlled laboratory experiment, we find that when a leader feels a low sense of belongingness, there is a positive relationship between a leader’s sense of uniqueness and perceptions of leader authenticity. When a leader feels a low sense of uniqueness, there is a positive relationship between a leader’s sense of belongingness and perceptions of leader authenticity. This is because followers perceive this leader as having high self-concept consistency. (shrink)

'Propositionalism' is the widely held view that all intentional mental relations-all intentional attitudes-are relations to propositions or something proposition-like. Paradigmatically, to think about the mountain is ipso facto to think that it is F, for some predicate 'F'. It seems, however, many intentional attitudes are not relations to propositions at all: Mary contemplates Jonah, adores New York, misses Athens, mourns her brother. I argue, following Brentano, Husserl, Church and Montague among others, that the way things seem is the way they (...) are, and that propositionalism must be abandoned. (shrink)

The long-standing debate between cognitive and feeling theories of emotion stems, in part, from the assumption that cognition and thought are abstract, intellectual, disembodied processes, and that bodily feelings are non-intentional and have no representational content. Working with this assumption has led many emotions theorists to neglect the way in which emotions are simultaneously bodily and cognitive-evaluative. Even hybrid theories, such as those set forth by Prinz and Barlassina and Newen, fail to account fully for how the cognitive and bodily (...) elements of emotion are integrated. As a result, such accounts are unable to provide an adequate characterization of the intentionality or phenomenology of emotions. I will argue that an enactive account of emotions, one which characterizes them as a way of engaging with and making sense of one’s surroundings, can help us to overcome this false dichotomy between cognitive and body elements. What I call ‘ affective framing’ is at the core of emotional experience. It is the way in which we engage with and appraise our surroundings in and through bodily feelings of caring, so that the bodily and cognitive elements of emotion necessarily are fused. The notion of affective framing not only helps to clarify the relationship between bodily and cognitive elements of emotion, but also offers a useful way to make sense of both the intentional directedness and phenomenal character of emotional experience. (shrink)

Some critical philosophers of race have argued that whiteness can be understood as a technology of affect and that white supremacy is comprised partly of unconscious habits that result in racialized perception. In an effort to deepen our understanding of the affective and bodily dimensions of white supremacy and the ways in which affective habits are socially produced, I look to insights from situated affectivity. Theorists in this field maintain that affective experience is not simply a matter of felt inner (...) states, but rather socially and environmentally embedded and fundamentally relational. Jan Slaby presents the concept of an ‘affective arrangement’ as a way to approach affectivity in terms of relational dynamics unfolding within a particular setting. Applying this concept to the societal level, Paul Schuetze introduces the notion of ‘affective milieu.’ I argue that these notions of ‘affective arrangement’ and ‘affective milieu,’ together with an organicist account of habit, can help to illuminate the workings of white supremacy in the United States. My proposed account highlights the extent to which white supremacy is an affective, bodily phenomenon and how racist habits are formed over the course of learning and ongoing affective engagement, in the context of various social settings. Crucially, these affective habits are fully bound up with habits of appraisal, interpretation, and judgment, and therefore inseparable from how subjects come to see and understand their world. (shrink)

This rich and varied collection of essays addresses some of the most fundamental human questions through the lenses of philosophy, literature, religion, politics, and theology. Peter Augustine Lawler and Dale McConkey have fashioned an interdisciplinary consideration of such perennial and enduring issues as the relationship between nature and history, nature and grace, reason and revelation, classical philosophy and Christianity, modernity and postmodernity, repentance and self-limitation, and philosophy and politics.

The title of this book is somewhat misleading. It is not a straightforward text on Kant’s methodology. Rather, the author uses Kant’s methods of analysis and synthesis as a backdrop in order to “complete the task where Kant left off”. The “task” is varyingly described by the author as that of leading us back to the “engendering archê” or the “originary”. This journey back to the originary will presumably allow us to explain the “world’s worlding”. The book draws on a (...) broadly phenomenological interpretation of Kant and thus emphasizes, a la Heidegger, the role of the imagination in Kant’s philosophy. Indeed, according to the author, Kant’s first Critique heralds the deep and profound notion that the “way to truth” is through the imagination. Again echoing Heidegger, the author takes it to be an unfortunate fact that Kant “shrunk back from this abyss”. Despite Kant’s timidity, however, the Critique is nevertheless said to provide us with the resources for a robust phenomenology. (shrink)

Stories consist largely of representations of the human social environment. These representations can be used to influence the behavior of others (consider, e.g., rumor, propaganda, public relations, advertising). Storytelling can thus be seen as a transaction in which the benefit to the listener is information about his or her environment, and the benefit to the storyteller is the elicitation of behavior from the listener that serves the former’s interests. However, because no two individuals have exactly the same fitness interests, we (...) would expect different storytellers to have different narrative perspectives and priorities due to differences in sex, age, health, social status, marital status, number of offspring, and so on. Tellingly, the folklore record indicates that different storytellers within the same cultural group tell the same story differently. Furthermore, the historical and ethnographic records provide numerous examples of storytelling deliberately used as a means of political manipulation. This evidence suggests that storyteller bias is rooted in differences in individual fitness interests, and that storytelling may have originated as a means of promoting these interests. (shrink)

Street’s “Darwinian Dilemma” is a well-known epistemological objection to moral realism. In this paper, I argue that “third-factor” replies to this argument on behalf of the moral realist, as popularized by Enoch :413–438, 2010, Taking morality seriously: a defense of robust realism, Oxford University Press, Oxford, 2011), Skarsaune :229–243, 2011) and Wielenberg :441–464, 2010, Robust ethics: the metaphysics and epistemology of godless normative realism, Oxford University Press, Oxford, 2014), cannot succeed. This is because they are instances of the illegitimate form (...) of reasoning known as “bootstrapping.” The phenomenon of bootstrapping has been discussed in detail, most notably by Vogel :602–623, 2000) and Cohen :309–329, 2002), in a different context as an objection to reliabilism and related theories of knowledge. I introduce four different characterizations of the error of bootstrapping from the epistemic literature in order to argue that the form of reasoning exemplified by third-factor replies would be deemed illegitimate by every one of them. I conclude that the moral realist should abandon third-factor replies, or else suggest a novel diagnosis for what goes wrong in bootstrapping cases that does not apply equally to the realist’s form of argument. However, I am not optimistic about the prospects for this latter strategy. (shrink)

Embodied Selves and Divided Minds examines how research in embodied cognition and enactivism can contribute to our understanding of the nature of self-consciousness, the metaphysics of personal identity, and the disruptions to self-awareness that occur in case of psychopathology. The book reveals how a critical dialogue between Philosophy and Psychiatry can lead to a better understanding of important issues surrounding self-consciousness, personal identity, and psychopathology.

Argues that the War on Drugs and policies that deny convicted felons equal access to employment, housing, education and public benefits create a permanent under-caste based largely on race. Reprint. 12,500 first printing.

This interdisciplinary book considers the relationship between language and thought from a philosophical perspective, drawing both on the philosophical study of language and the purely formal study of grammar, and arguing that the two should align. The claim is that grammar provides homo sapiens with the ability to think in certain grammatical ways and that this in turn explains the vast cognitive powers of human beings. Evidence is considered from biology, the evolution of language, language disorders, and linguistic phenomena.

Prenatal genetic testing is becoming available for an increasingly broad set of diseases, and it is only a matter of time before parents can choose to test for hundreds, if not thousands, of genetic conditions in their fetuses. Should access to certain kinds of fetal genetic information be limited, and if so, on what basis? We evaluate a range of considerations including reproductive autonomy, parental rights, disability rights, and the rights and interests of the fetus as a potential future child. (...) We conclude that parents should be able to access information that could be useful during pregnancy, but that testing for non-medical information should be limited. Next, we argue that the government lacks a compelling state interest in regulating prenatal genetic testing and propose that regulation should occur through medical professional organizations. Finally, we present a framework for determining what testing physicians should recommend, offer neutrally, or not offer at all. (shrink)